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Pregablin (Lyrica)

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Georgie View Drop Down

Joined: Jun/17/2015
Location: england
Posts: 62
Post Options Post Options   Thanks (0) Thanks(0)   Quote Georgie Quote  Post ReplyReply Direct Link To This Post Topic: Pregablin (Lyrica)
    Posted: Jul/27/2015 at 9:07am
Just been researching and for nerve pain apparently the minimum dose is 75mg twice a day. I'm on 50mg once at night? I'm getting all the side effects but none of the benefit? I've got a telephone appointment on Wednesday as the 2 decent docs go on holiday Thursday morning for 2 weeks :@
Just wondering if my dose sounds right? I'm constantly tired since being on it and constantly not getting enough sleep but getting no relief
Sciatica and Costochondritis sufferer in England
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Stevie View Drop Down
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Joined: Jun/01/2008
Location: Arizona
Posts: 27314
Post Options Post Options   Thanks (0) Thanks(0)   Quote Stevie Quote  Post ReplyReply Direct Link To This Post Posted: Jul/27/2015 at 9:57am

There is no set dose of Pregabalin (Lyrica) that is right for all.  I actually couldn't handle a starting dose of 50mg at night either.  I would wake up in the morning feeling like I was on a rocking ship.  Side effects finally did diminish, but the only dose I could ever take during the day was 25mg.  (Yes---it does come in that dose so don't allow anyone to tell you it doesn't).  I've found over the years both personally and from members here that everyone reacts differently.

My advice to to use the smallest amount possible until you see benefits and not side effects.  Then, stay on the lowest dosage possible.  This drug does work, and unfortunately, because of dosing too high right off the bat, people give up on it and don't get a chance to adjust to side effects.

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My journey with chronic pain began over 30 years ago, while as a young nurse working spinal rehab, I injured my back lifting a patient. I am now fused from L2-S1. I have multiple thoracic and cervical issues. I'm a retired RN/PA and I know and understand the frustrations on both ends of the treatment spectrum of dealing with CP. It's been my goal since 2008, when we started this site, to reach out and help as many people in pain as possible. We will continue the fight as long as we can. Please, if you can help us continue to help you and others, donate. Thank you.
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Tas View Drop Down
Senior Member
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I Donated to CPS 2013-2016

Joined: Jan/21/2013
Location: Hobart, Tasmania
Posts: 2827
Post Options Post Options   Thanks (0) Thanks(0)   Quote Tas Quote  Post ReplyReply Direct Link To This Post Posted: Jul/27/2015 at 5:00pm

I started off using 25mg in  the morning and at night, but eventually the pain in the left knee/leg was so intense at 2.30am I would wake up. It was decided that this was due to the muscle cramping up due to the pain level.

After talking to my GP we increased the doseage to 25mg, morning, lunchtime and night, plus 2.5mg diazapam in the morning and 5mg diazapam (Valium) at night.

This improved things until recently, must have been for about two years. Recently visited my PM specialist and he told me to get off diazapam and increase Lyrica doseage to 600mg.  

My GP and I read the recommendation and could not believe it. Have since changed PM specialists with the advice of my GP and neurosurgeon.

I seem to remember that like most drugs it did take some time to kick in.


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L1/2 Mild bilateral facet astropathy. L2/3 same as L1/2. L3/4 ditto. L4/5 Disc bulge indenting anterior thecal sac. Bilateral facet astropathy. Mild canal and left foraminal stenosis. L5/S1 Severe disc narrowing with extensive osteophytes. Broad based disc osteophyte protusion indenting anterior thecal sac and resulting in a right foraminal stenosis. Exiting L5 nerves intact. Osteophytic contact with descending right S1 nerve root. Conclusion_ Severe degenerative disc changes L5/S1 with disc-osteophyte protusion. Moderate disc bulge L4/L5 Moderate central spinal stenosis with obileration of the epidural fat and distortion of the thecal sac. L5/1 Decreased disc height and signal. Super Ventricular Tachacardia. (SVT) Type 2 Diabetes, Arthritis knees and hips.
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tkay View Drop Down
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I Donated to CPS 2013-2018

Joined: Dec/28/2009
Location: Michigan
Posts: 7932
Post Options Post Options   Thanks (0) Thanks(0)   Quote tkay Quote  Post ReplyReply Direct Link To This Post Posted: Jul/27/2015 at 9:17pm

I started out the first time on Lyrica at 25mg and then it was increased over time. It took a month to feel really good results. The side effect that I sort of enjoyed but others did not is that I got euphoric feeling, I am a bit giggly and happy.

I was taking 150mg a day, 75mg in the AM and 75mg in the PM.

Be patient it takes time. If Lyrica doesn't work there are other medications that can be tried. Stevie would be able to tell you about them.

btw..I use Lyrica for Fibromyalgia pain.
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Madiashell View Drop Down

Joined: Apr/23/2016
Location: Tennessee
Posts: 4
Post Options Post Options   Thanks (0) Thanks(0)   Quote Madiashell Quote  Post ReplyReply Direct Link To This Post Posted: Apr/23/2016 at 2:31pm
Lyrica can be one of the worst medications when it comes to side effects, but it if it helps you in the SLIGHTEST, just know that with time the side effects often do go away, and if it's something you can handle, it may be worth waiting it out to see if it's the right medication for you. I think a lot of people may not ever really figure out the benefits of lyrica because they don't tough it out through the side effects... not to say that is necessarily wrong for them, it's different for everyone. But I know it basically ended my migraines, and makes me able to walk in the morning, and if I had stopped taking it when I wanted to in the beginning because of the side effects like drowsiness and lightheadedness, I don't even know if I would be alive anymore. It is a miracle drug for me now, but I had a lot of side effects when I started, and I've even been in the hospital a couple of times without it, and when I start it back I'll have side effects. It's just they go away with normal use and for me it's more than worth it. There are a lot of factors in deciding whether or not it might be worth it for you or not, though. As for the dosage, there is no dosage that is too small especially if you are having side effects. If you are taking it how the doctor prescribed it to you, then you're absolutely fine.
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Hazy-Daisy View Drop Down
I Donated to CPS 2016

Joined: May/13/2016
Posts: 15
Post Options Post Options   Thanks (0) Thanks(0)   Quote Hazy-Daisy Quote  Post ReplyReply Direct Link To This Post Posted: May/14/2016 at 7:31pm
My rheum. started me with 50 1x a day for a week, then upped to 2x a day. After that first month, up to 75 2x...we started slowly, so that I had time to deal with any side effects since there are many for some people. I'm currently at 100 2x day. Everybody is different, but when I asked, he told me, most of his patients find their best results somewhere around 300. We're just taking it month by month - and I have noticed the noise level of some of my nerve pain is better. I have other things going on, so this is not my primary issue, but to have any relief at this point has been wonderful. Lyrica wise, I am diabetic/and have fibromyalgia with history of nerve pain in other variables.

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Hangingon View Drop Down
Prior Member
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I Donated to CPS 2015

Joined: Oct/29/2013
Location: Georgia, Us
Posts: 1667
Post Options Post Options   Thanks (0) Thanks(0)   Quote Hangingon Quote  Post ReplyReply Direct Link To This Post Posted: May/14/2016 at 11:43pm
well I can't take it I tried all the different forms . First was the capsules got terribly sick close to hospitilazation, thought it was the filler they use lactose I'm close to complete lactose intolerance. Then tried the tablets got deathly sick, went to the liquid form same thing. But I too have other issues I have liver disease from having hep c for over 30 yrs (luckily I am cured of that went thru the trial, still have 1st stage cirrhosis),got it from the air guns when I joined the Air Force. I have horrid side effects from a lot of meds. My Sis takes it with no problems.
So glad you found a way to make it work for you.
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eileenbunny View Drop Down
Senior Member
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I Donated to CPS 2014-2016

Joined: Mar/21/2011
Location: Columbia, MD
Posts: 619
Post Options Post Options   Thanks (0) Thanks(0)   Quote eileenbunny Quote  Post ReplyReply Direct Link To This Post Posted: May/15/2016 at 9:34pm
I took it for migraine and nerve pain and it helped a lot.  The side effects went away after about a month.  I can't remember what dose I was taking though.  I had to stop when I got pregnant and I haven't been able to start again because I was breast feeding and then got pregnant again.  I'll probably get back to it in another year when I'm done with all this baby making.
Chronic daily headache without real designation resulting from severe meningitis

Non-hodkins lymphoma survivor since 2003
Ruptured disk at C5-C6
Inferior alveolar nerve damage
Depression, PTSD with dissociative tendencies
I also have some yet to be diagnosed immune deficiency that is causing fatigue and severe joint pain.
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